SYLLABUS of LPUNEST
(PG Pharmacy)

Grammar: Parts of speech – Noun, Pronoun, Adjective, Adverb, Verb, Preposition, Conjunction Interjection; Tenses – Present, Past and Future Tense in Active and Passive Form; Modal Verbs – Can, Could, May, might, Should, Will, would, punctuation, independent and dependent clauses, sentence and its types, determiners

Associative Language Skills: Vocabulary – Antonyms, Synonyms, Homonyms, Homographs, one-word substitution, Word Analogies, Idioms and Phrases.

Common Errors: Sentence Correction and Error Finding Exercises

Comprehension Passages: Closed and Open paragraphs, identifying key ideas or theme.

Dravyaguna: History of dravyaguna, Classification of Dravya, Rasa-panchak, Karma, Jangam Dravya, Posology, Time of administration, Mishrak varga, Controversial drugs, Nighantus

Pharmacognosy: History, Carbohydrate, Tannins, Glycoside, Resins, Alkaloids, Cell inclusions, Drug evaluation, Volatile drugs, Marine drugs
Rasa-Shastra & Bhaishjya Kalpana: Rasa Shala including GMP, Paribhasha, Yantra- Musha & Puta, Rasa kalpa, Classification of Rasa dravya, Parada, Fundamental principles of B.K and Saveeryata, Panchvid Kasaya Kalpana, Dwatyka (Secondary) Kalpana, Mana

Analysis: T.L.C- H.P.T.L.C, H.P.L.C, Gas chromatography, Physico-chemical parameters, Standardization of Ayurvedic formulations, U.V Spectroscopy, I.R, N.M.R, Mass spectroscopy, Titration

Pharmaceutics: Composition & physical states of matter, Colligative Properties, Thermodynamics, Chemical Equillibria, Phase rule, Refractive index, Solutions, Electrochemistry, Kinetics, Matter, properties of matter, Micrometrics and powder rheology, Surface and interfacial phenomenon, Viscosity and rheology, Dispersion systems, Complexation, Buffer, Solubility, Introduction to Pharmaceuticals, dosage form, route of administration, Sources of drug information, Allopathic dosage form, Crude extract, Allergenic extract, Ayurvedic system and Homeopathic system of medicine, Biological products, GMP and validation, Pharmaceutical Plant, location, layout, Dosage Form Necessities and Additives, Powders, Capsules, Tablets, .Parenteral-product requiring sterile packaging, aerosol ,emulsion, suspension, percolation, Suppositories, Semisolids, Liquids (solutions, syrups, elixirs, spirits, aromatic water, liquid for external uses), Ophthalmic preparations, Preformulations, Radio Pharmaceuticals, Stability of formulated products, Kinetic Principles and Stability Testing, Novel and Controlled Drug delivery system, Cosmetics, Packaging Materials, Pilot plant scale up techniques, Plant Cell and Tissue Culture, Animal Cell Culture, Recombinant DNA Technology, Process and Applications, Biotechnology Derived Products, Proteomics, Formulation of Proteins and Peptides, Fluid flow, Heat transfer, Evaporation, Distillation, Drying, Size reduction and size separation, Extraction, Mixing, Crystallization, Filtration and Centrifugation, Refrigeration and air conditioning, Material of constructions, Automated process control systems, Industrial hazards & safety precautions, Planning and Forecasting, Research Management, Marketing Research, Human resource and development (HRD), GATT, TRIPS, Standard institutions and regulatory authorities, The Pharmacy Act 1948 (inclusive of recent amendments), Drugs and Cosmetics Act 1940, Rules 1945, including New Drug applications, Narcotic Drugs and Psychotropic Substances Act, Drugs and Magic Remedies (Objectionable Advertisements) Act 1954, Medicinal and Toilet Preparations (Excise Duties) Act 1955, Rules 1976, Medical Termination of Pregnancy Act 1970 and Rules 1975, Prevention of Cruelty to Animals Act 1960, Drug (Price Control) Order, Shops and Establishment Act, Factory Act, Consumer Protection Act, Indian Pharmaceutical Industry- An Overview, Minimum Wages Act 1948, maceration process, Study of current patent and proprietary products, generic products and selected brand products, indications, contra indications, adverse drug reactions, available dosage forms and packing, Compounding and dispensing of different formulation prescriptions, Reading and counselling of prescriptions from the clinical practice, Bio-pharmaceutics, Bio-availability & Bio-equivalence, Bio- pharmaceutical statistics. Pharmacovigilance, Pharmacoeconomics, Drug distribution systems in hospitals, Entrepreneurship opportunity for pharmacy graduates.

Pharmaceutical Analysis: Importance of quality control in pharmacy, Acid-base titrations, Non-aqueous titrations, Oxidation- reduction titrations, Redox titrations, Precipitation titrations, Complexometric titrations, Gravimetry, Extraction techniques, Electrochemical methods of analysis (Potentiometry, Conductometry, polarography, amperometric titrations), Miscellaneous methods of analysis (Kjeldahl method, oxygen flask combustion method, diazotization titrations, Karl Fischer titrations), Calibration of instruments, General principles of spectroscopy, Ultraviolet-visible Spectrometry, Spectrofluorimetry, Flame photometry & Atomic Absorption Spectrometry, Infrared spectrometry, Proton nuclear magnetic resonance spectrometry, Mass spectrometry, Nephelometry & Turbidimetry, Chromatography, Miscellaneous, Analytical instrumentation used in Pharmaceutical.

Pharmacology: General Pharmacology, Cell physiology, Anatomy and Physiology of different organ, Gastrointestinal tract, Respiratory System, Autonomic nervous system, Sense organs, Skeletal System, Central Nervous system, Urinary System, Reproductive System, Endocrine Glands, Cardio vascular system, Lymphatic system. Anatomy and Physiology of different organ, Pharmacology of drug acting on Peripheral Nervous System, Central Nervous System, Cardiovascular system, Urinary system, Respiratory system, Gastrointestinal tract, Endocrine system, Chemotherapy, Autacoids and their Antagonists Drugs acting on blood and blood formation, urinary system, narcotic analgesics, NSAIDs, Vitamins & Minerals, Neoplastic diseases, Immnopharmacology, chronopharmacology, toxicology, Chemotherapy of malignant diseases, Peptides and proteins as mediators, Clinical research and Pharmacovigilance, concepts of pharmacotherapy, Therapeutic Drug Monitoring, Adverse drug reaction, Biochemistry of cell, Carbohydrates, Proteins, Lipids, Vitamins, Biological oxidations & reductions, Enzymes, Nucleic acids, Hereditary diseases, Microscopy and staining technique, Biology of Microorganisms, Fungi and Viruses, Aseptic Technique, Sterilization & Disinfection, Microbial spoilage, .Immunology and health, Vaccines & Sera, Microbial Assay, Pathophysiology of different diseases, Basic principles of cell injury and adaptation, mechanisms of inflammation and repair, Hypersensitivity, Auto-immunity & diseases of immunity, Neoplastic diseases, Shock, Biological effects of radiation, Protein calorie malnutrition, vitamins, obesity, Starvation, Infectious diseases, General Principles, preparation, maintenance, analysis of observational records in clinical Pharmacy, Therapeutic drug monitoring, adverse drug reaction (ADR), Clinical trials, Drug information services, Drug interactions, Age related drug therapy, Pharmacovigilance, Drug therapy in gastrointestinal, hepatic, renal, cardiovascular and respiratory Disorders, neurological and psychological disorders, urinary system, infective meningitis, TB, HIV, malaria and filarial, parathyroid disorders, diabetes mellitus, menstrual cycle disorders, menopause and male sexual dysfunction, leukemia, lymphoma and solid tumors, rheumatic, eye and skin disorders.

Pharmaceutical Organic Chemistry: General principles in organic chemistry, Different classes of compounds, protection & deprotection of functional groups. Aromaticity and different aromatic classes of compounds, Polycyclic aromatic hydrocarbons, Carbonyl Chemistry, Heterocyclic Chemistry, Bridged rings, Kinetic & thermodynamic control, Stereochemistry, Carbohydrates, Amino acids & proteins, Organometalic chemistry, Pericyclic reactions, Pharmaceutical Impurities, Monographs, Isotopes, Therapeutic classes of different drugs, Drug metabolism, Drug nomenclature, classification, physicochemical properties, mode of action [MOA], structure activity relationships [SAR] of therapeutic agents, Combinatorial chemistry. Carbohydrates: Monosaccharides, Disaccharides, Polysaccharides, Amino acids, Peptides, Proteins, Nucleic acid, fats. Structure, nomenclature and properties and reaction mechanism of organic compounds: alkanes, alkenes, alkynes. Structure, nomenclature and properties and reaction mechanism of organic compounds: benzene, phenol, arene, Structure, nomenclature and properties and reaction mechanism of organic compounds: alkyl halides, alcohols, ethers, epoxides, amines, aldehydes, ketones, carboxylic acids, functional derivatives of carboxylic acids, Stereochemistry, relative and absolute configuration of organic molecules.

Medicinal Chemistry and Phytochemistry: Classification, structure, SAR, synthesis and medicinal uses of following class of drugs: Non Opioid Analgesics and NSAIDS, Opioid analgesics & Anti-tussives, Anti-histamines, Classification, structure, SAR, synthesis and medicinal uses of following class of drugs: Chemotherapeutic agents used in Protozoal, Parasitic and other infections, Anti-viral including anti-HIV, Antineoplastics agents, Drug Metabolism, Diagnostic agents, Pharmaceutical Aids, Classification, structure, SAR, synthesis and medicinal uses of following class of drugs: Steroids and related drugs, Diuretics, Drugs acting on cardio-vascular system, General anaesthetics & Local anaesthetics. Adrenergic and Cholinergic Drugs, Cardiovascular Drugs, Central Nervous System Drugs, Antiasthmatic Drugs, Anti-microbial Agents, Antidiabetic Drugs, Antiulcer Drugs, NSAIDS. Classification, structure, SAR, synthesis and medicinal uses of following class of drugs: Cholinergics and Anti-cholinesterases, Adrenergic drugs, Drugs affecting central nervous. Classification of crude drugs, Factors influencing quality of crude drugs, Techniques in microscopy, Introduction to phytoconstituents, Principles of plant classification, Pharmaceutical aids related pharmacognosy, Animal products, Plant products, Study of allergens, hallucinogens, narcotics, toxic mushrooms, Natural pesticides and insecticides, Adulteration and evaluation of crude drugs, Quantitative microscopy, .Biogenetic pathways, Biological sources, salient morphological features, chemical constituents, and uses of Carbohydrates & lipids, Tannins, Volatile oils, Resinous drugs, Glycosides, Alkaloids, Herbarium, Extraction and Isolation Techniques, Phytopharmaceuticals, Quality control and Standardization of herbal drugs, Herbal formulations, Worldwide trade of crude drugs and volatile oils, Herbal cosmetics, Plant Biotechnology, Traditional herbal drugs, Plants based industries and research institutes in India, Patents.

Section 1
Basic concepts of chemistry:
Strength of solution, molarity and molality, normality, mole fraction and parts per million.

Section 2
Water, Acids and Bases:
Theories of acids and bases, water homeostasis, buffer solutions, choice of indicators for acid-base titration.

Section 3
Carbohydrates:
Introduction and classification of carbohydrates, digestion of the carbohydrates, biological significance, important properties of carbohydrates.

Section 4
Lipids:
Introduction and classification, properties of fat; lipoproteins; steroids and triglycerides.

Section 5
Proteins:
Introduction to amino acids, classification of proteins, structure of proteins; properties of proteins.

Section 6
Enzymes:
Introduction and classification; factors affecting enzyme action; enzyme inhibition; iso-enzymes.

Section 7
Nucleic acids:
Introduction and classification; DNA and RNA; Watson and Crick Model; types of DNA.

Section 8
Vitamins and Co-enzymes:
Introduction and classification, water soluble vitamins; fat soluble vitamins, coenzymes and cofactor.

Section 9
Hormones:
Introduction and classification; mechanism of action and secondary messenger; amino acid and peptide hormones; steroid hormones.

Section 10
Immunology:
Innate and adaptive immunity; cellular and humoral immunity; antigen and antibody interaction; antigen processing and presentation.

Section 1
Introduction to general microbiology:
Introduction; history of microbiology, Relationship of microbes to human, Normal micro flora of human.

Section 2
Microscopy:
Introduction, principle and application of light microscope, Fluorescent microscope; Phase contrast microscope; Electron microscope.

Section 3
Sterilization:
Introduction and its types; principle, procedure and application of each types of sterilization; various efficiency testing to sterilizers and sterilization procedures.

Section 4
Antiseptics and disinfectants:
Introduction and classification; mode of action; application of various disinfectants and the precautions during disinfectants use.

Section 5
Classification of microbes:
Prokaryotes and eukaryotes; general characteristics; classification and clinical significance of bacteria, fungi, virus and parasite.

Section 6
Morphological classification of bacteria:
General features and classification of bacteria, bacterial cell structures, Gram❜s staining and its applications.

Section 7
Growth and nutrition of microbes:
Classification of microorganisms on the basis of nutrition, general growth requirements of the bacteria, physical conditions required for growth, growth curve of bacteria.

Section 8
Culture media:
Introduction and classification of culture media, composition, principle and applications of each type of culture media, aerobic culture methods, anaerobic culture methods.

Section 9
Antibiotics susceptibility Testing :
Introduction, principle, modes of action and its applications, MIC, MBC and strokes methods, Kirby Bauer method, gradient susceptibility testing such as MIC by E-test.

Section 10
Immunology:
Innate and adaptive immunity; cellular and humoral immunity; antigen and antibody interaction; antigen processing and presentation.

Unit Broad Topic Subtopic
1 Cell and Cell organelles Eukaryotic and prokaryotic cell, plasma membrane, cell wall, nucleus, mitochondria, golgi bodies, lysosomes, endoplasmic reticulum, peroxisomes, plastids, vacuoles, chloroplast, structure & function of cytoskeleton and its role in motility
2 Cellular Processes Operon, interrupted genes, gene families, structure of chromatin and chromosomes, unique and repetitive DNA, heterochromatin, euchromatin, transposons, mitosis and meiosis, their regulation, steps in cell cycle, and control of cell cycle; DNA replication, transcription and translation
3 Reproductive Physiology Spermatogenesis and its hormonal regulation, formation of semen, fertility standards, ultrastructure of sperm, sperm maturation.
Ovary – Structure, folliculogenesis, ovulation, corpus luteum, atresia, menstrual cycle
4 Embryonic Development Fertilization, first week of development, second week of development, third week of development, fourth week of development, fifth through eighth week of development, fetal period, embryonic development in each trimester of pregnancy, placenta and amniotic fluid, labor
5 Reproductive disorder and Diagnostic Analysis Sexual differentiation and developmental abnormalities in male & female, menstrual disorders – Precocious, delayed or absent puberty, fertility disorders – sexual dysfunction, infertility
6 Assisted Reproductive Techniques Ovulation induction, oocyte retrieval, in vitro maturation, in vitro fertilization (IVF), gamete intra-fallopian transfer (GIFT), Intracytoplasmic sperm injection (ICSI), cryopreservation of gametes & embryos

Anatomy: Upper limb –muscles ,bones and joints ,Lower limb –muscles ,bones and joints, Head and Neck, Central nervous system, Thorax –Lungs and Heart, Abdomen.

Physiology: Functions of endocrine glands, Cardiovascular system, Respiratory system, Nervous system, Blood and its functions, Musculoskeletal system, Immunity.

Exercise Therapy: Active exercises, Passive exercises, Resisted exercises, Starting positions and derived positions, Suspension therapy.

Electrotherapy: Hydrotherapy, Short wave diathermy, Ultrasound therapy, Transcutaneous electric stimulation, Electric muscular stimulation, Microwave diathermy , LASER, Ultraviolet rays, Compression therapy.

Biomechanics: Structure of shoulder,elbow and wrist joint,Structure of Hip joint, Structure and function of Tibiofemoral joint, Structure and function of Patellofemoral joint, Joints of Ankle and foot complex, Plantar arches and muscles of ankle and foot, Kinetics and Kinematics of Posture, Analysis of Postures, Abnormal Gaits.

Clinical Neurology: Structure and Function of Brain and Spinal Cord ,Blood Supply of Brain and Spinal Cord , Disorders of CNS , Disorders of PNS, Tumors of Brain and spinal cord, Head Injury, Stroke, Parkinsonism, Multiple Sclerosis, MND,Poliomyelitis, Cervical and Lumbar Disc Lesions, Myopathies , Infections of Brain and Spinal Cord.

Clinical Orthopedics: Classification of fractures, Fracture healing, Treatment of fractures, Splints & tractions, Treatment and complications of fracture, Dislocations and subluxation, Tennis elbow, Golfer’s elbow, Ganglion, Carpal tunnel syndrome, Trigger finger, Torticollis, cervical rib, Rheumatoid arthritis, Gout and pseudogout ,Osteoarthritis, Cervical spondylosis, Classification of amputation, Levels of amputation, Complications of Amputations, Rickets, Osteomalacia, Osteoporosis, Dupuytren’s contracture, Frozen shoulder, De-quervains disease, Meralgia paraesthetica, Injuries around Shoulder, Elbow, Wrist, Hand, Pelvis, Hip, Knee, Ankle, Foot,Spine, Congenital abnormalities.

Clinical Cardio Respiratory: Basic anatomy of heart and blood vessels, Basic physiology of cardiovascular system, Investigations in cardiology, Cardiac Medications, Ischemic Heart Diseases, Cardiomyopathies, Dilated Cardiomyopathies Conduction abnormalities of heart, Congenital Heart Diseases,Cardiac Surgeries, Peripheral Arterial Diseases, Lymphatic Diseases,Venous Diseases,Intensive Cardiac Care.

Community Based Rehabilitation: 2

1: Introduction to rehabilitation medicine : Conceptual framework of rehabilitation, Roles of rehabilitation team members, Definitions and various models of rehabilitation, Community based rehabilitation, Preventive rehabilitation, Activities of daily living : Definition of ADL, Scope & importance of ADLs, Wheel chair activities, Teaching training of bed activities, Training of locomotor activites, Teaching training of self care activities Sociolegal aspects of rehabilitation : Statutory provisions, Schemes of assistance to persons with disability Vocational Rehabilitation : Prehension, Disabled hand, Vocational rehabilitation team, Principles in the management of vocational problems, Principles of U.L. Prosthetics and Orthotics, Principles of L.L. Prosthetics and Orthotics, Spinal orthosis.

Pediatrics and Geriatrics: Normal Developmental milestones of infant, Primitive reflexes, Congenital Disorders of infants, Orthopeadic, Neurological, Cardio pulmonary, Psychiatric and behavioural disorders of paediatrics, Normal response to ageing, Degenerative disorders of Geriatric Population, Cardiological, pulmonary, musculoskeletal and neurological disorders of geriatric population, Falls and Falls prevention.

Obstetrics And Gynaecology: Physiology of pregnancy, The breast, Urinary tract and anorectal region, Complications of pregnancy, The antenatal period Post natal problems, Common gynecological conditions: Salpingitis, Uterine fibroids, Amenorrhea, Dysmennorhea, Premenstrual syndrome, Menorrhagia, Endometriosis, Incontinence of urine, Lower urinary tract dysfunction, Urinary dysfunction: Incontinence of urine, Lower urinary tract dysfunction.

Physiotherapy in Orthopaedic Conditions: Assistive devices , Approach to patient with trauma,orthopaedic injury, Complications of fractures, Assessment and management of orthopaedic disorders of upper limb,lower limb, Assessment and management of rheumatoid arthritis and osteoarthritis, Assessment and management of amputation, Assessment and management of osteomylitis, Assessment and management of tuberculosis of bones, Assessment and management of Caries spine, Assessment and management of benign tumour and malignant tumours,Assessment and Management of poliomyelitis, peripheral nerve injuries of upper limb, peripheral nerve injuries of lower limb.

Physiotherapy in Neurologic Conditions: Assessment and Management of Stoke, MS, Parkinson’s, MND,Tumors of Brain and Spinal Cord, Traumatic Head and spine injury, Demyleinating diseases of brain and spinal cord,Degenerative diseases of brain and spinal cord, Peripheral Nerve injuries and disorders, Infectious disorders of brain and spinal cord, cerebellar disorders, ANS dysfunctions, Radiculopathies. Physiotherapy in Cardiopulmonary Conditions:Objective and subjective assessment of cardiopulmonary patient, Breathing techniques and airway clearance techniques used in cardiopulmonary patient, Rehabilitation of cardiac and pulmonary patient, Cardiopulmonary physiotherapy for musculoskeletal ,neurological disorders, Physiotherapy techniques in intensive care unit, Cardiopulmonary physiotherapy for neonates and pediatric patients, Cardiopulmonary physiotherapy for geriatrics and transplant patients.

Physiotherapy in Sports Medicine: Multidisciplinary approach, Principles of athletic training, Classification of sports injuries, Overuse injuries, Principles of injury prevention, Response of body to exercises, Types of training: Aerobic training, Anaerobic training. Paediatrics And Geriatrics Physiotherapy: Genetic Disorders, Positioning and handling to enhance the motor function, Neural tube defects, Muscle disorders in paediatrics, Vitamin Deficiency in Paediatrics, Cardiorespiratory in paediatrics, Impaired motor control, Impaired posture and mobility, Evaluation of seriously ill geriatrics, Exercise and physical activity for older adults, Balance and falls, Environmental design for geriatrics, Home health Physical therapy.

Research Methodology and Biostatistics: Foundations of Research: Meaning, Objectives, Motivation, Utility. deductive and inductive theory.
Problem Identification & Formulation – Hypothesis – Qualities of a good Hypothesis –Null Hypothesis & Alternative Hypothesis. Hypothesis Testing – Logic & Importance.

Research Design: Concept and Importance in Research – Features of a good research design – Exploratory Research Design – concept, types and uses, Descriptive Research Designs – concept, types and uses. Experimental Design: Concept of Independent & Dependent variables.

Qualitative and Quantitative Research: Qualitative research – Quantitative research – Concept of measurement, causality, generalization, replication.

Measurement: Concept of measurement– Validity and Reliability. Levels of measurement – Nominal, Ordinal, Interval, Ratio.

Sampling: Concepts of Statistical Population, Sample, Sampling Frame, Sampling Error, Sample Size, Non Response. Characteristics of a good sample. Probability Sample – Simple Random Sample, Systematic Sample, Stratified Random Sample & Multi-stage sampling. Determining size of the sample.